When a mission for the Daily Bugle is available, start it. Go inside the building and Robbie will assign you a project when you talk to him. Leave the building to start the mission, and then go back in. Wait inside the building until the mission failed message appears. When it asks you to select either "Retry" or "Do something else", select "Do something else". You will then appear at the top of the building as Peter Parker. Walk over to the race, but do not start it; this will allow you to use punch. To get off the top of the building, walk over to the edge. Hold forward and repeatedly press punch. You will fall off the building to the ground. To discontinue playing as Peter Parker you must die.
In your last fight with Shriek, she temporarily takes away your Black suit and uses people from your imagination attack you. Wait until the Black suit recharges to switch over and detect your true enemies. Keep attacking Shriek until she changes you back to the old Spider-Man. Repeat these steps until she collapses.
Wait until Michael is preparing to rush you, then open the window. He will be temporarily weakened, giving you the chance to attack. Shriek will heal him at the cost of her health. Repeat this until he dies and she flees.
During your first encounter with Sandman, avoid attacking him. Instead, just try to stay close to him. Counter-attack him several times on various levels to finally battle him. You need the Black suit to damage him. Keep hitting him until you are prompted to give him a bath. Repeat until you defeat him.
The second battle with Sandman is simple. Just dodge when your Spidey senses alert you and run to the yellow circles that appear. Complete the prompts to throw TNT barrels at Sandman. Harry will eventually kill him.
Before fighting Venom, go to the upgrade menu and make sure you have the melee attack volley. Depending on your health level, you may or may not want to use the power up. At the right moment, jump over Venom, confuse him, and chip away at his health. Repeat until his black suit begins to "glow". Now, when you jump over him he will run away. Take this opportunity to use your new attack and chip at him, occasionally giving some hits. Keep hitting him until his "glow" gets stronger. Harry will eventually tell you to knock Venom into the air. He'll fall back to the ground confused, same as before. Repeat until his health is low and you can finish him off.
Use the following strategy to easily defeat Venom the first and second time you face. When you meet Venom at the construction site, you must beat him down in five minutes or else Mary Jane will die. The best way to do this is by defeating Venom in version one. Version two is slightly harder. Simply watch his five punch combo and the last punch, which is his super punch. After he is done with his combo, beat him up. Repeat until Venom turns into version three. Watch carefully and you should see a flashing symbol. Once you do, follow what the game instructs you to do and you should win.
The easiest way to defeat the second Venom is to jump around and fire adrenaline web. When his glow is high, go to the circle and press the selected button.
Once you defeat The Sandman for the first time during the “Mary Jane's Favorite Band" mission and before you "Meet Mary Jane At The Restaurant", you cannot remove the Black suit. During this time, which lasts until you start the next mission, you can wear the Black suit without any damage being done to you. Use this time to clear the city of all gang activity. This takes a long time but is easier with the Black suit.
As Black costume Spider-Man, find the meteorite fragments (small rock objects surrounded by a purple/pink glow) by listening for a pulsating sound. The louder it gets, the closer you are to the fragment.
After completing the Final Showdown mission, Go on the map and look for the Financial District. Go there and head to the left until you see a glass building. This is the construction site after it was broken Note: You can see the little square that you was fighting in with Venom and Sandman.
Go to the clock tower in Columbia and get on one of the four sides. Wall crawl up until you get to the clock. Keep wall jumping up until you fall inside. If you are in the black suit you will make a crack. You won’t be able to move unless you web swing, then you’ll will reappear. Note: This doesn’t work all of the time.
An easy way to defeat enemies is by jumping while repeatedly tapping both Attack buttons.
To defeat Apocalypse Gang members, Arsenic Candy girls, and Dr. Connor's Lizard Creations in one hit, jump up in the air and pull the enemy up to you. Then, immediately press B when they are close, then TRIANGLE repeatedly. You will pile drive their head in to the ground. This move will only defeat the lower level gang members in one hit. In order to do this on the ones with weapons, you must be Symbiotic Spider-Man in Rage mode. They will lose 75% of their health. For the order on the Dragon Tail members, this move will take down their health to around 90%.
You can move cars by finding a cardboard box in a warehouse or any other location. Push it outside into the street, then push the box into the car and the car will move just as if you were pushing the box.
The maximum height limit is about 850 feet in the air. To reach it, find a Dragon Tail Member and jump web yank. Press A when they are at your feet and you should jump up, then web yank them again and repeat. This only works with Dragon Tail Members since they will block your attack when you jump off them in the air. Even if they lose health at first, just keep doing it. Once they recover from the first jump, they will start blocking the attacks.
On the last Dr. Connors part 2 mission, hold Slow Motion while putting in the serum into the canister. As soon as you come into play, Web-Zip to the left onto the platform. Note: Do not jump--Web-Zip only. Stay there and do not move. No Lizards will appear so wait for the time to run out.
To minimize the distance you have to travel, go to the Daily Bugle. Get in between two smoke towers (use your Spider-Sense to find it). Look in the direction you want to go, then press SQUARE and tap Left Analog-stick Down.
When attempting to open the boarded windows, he will do a long jump towards you if you are far away from him, which takes a few seconds to recover from. Don’t stand in the yellow circles before he jumps. Instead, stand next to the wall opposite the windows. He will now jump to there and while he is recovering, pull down the boards. When he jumps into the light, attack him. Repeat this until him and his wife are defeated. Note: When he flies around, use the Spider-Wall to damage him and he will land
When you go to a crime area controlled by the police, you will be given a task involving a random gang. When these tasks are completed, the effectiveness of the police will increase as seen by the rings around the police symbol on the map. The more rings you have, the less likely it is for gangs to take control of police-controlled areas and the more likely it is for the police to take over gang controlled areas.