Bronze trophies
All Gummed Up - Lose any Story Mode level within 5 seconds
Clean-a-rama - Get a combo-pop of 100 or more germs with one shot
Feverish Cleaning - Complete a Story Mode level in under 30 seconds
Mother of all Pops - Pop a germ of size 25x or greater
Oozie - Fire 50 germs in a single Story, Duel, or Arcade level
The Inoculator - Survive for 5 minutes or more in Arcade Mode
The Marksman - Finish any Puzzle level with a single shot

Silver trophies
Germ-a-thon - Complete 20 different levels in a single run in Puzzle Mode
Micro-Cleaner - Complete all Story Mode levels
Photo Finish - Win the 15th round in a Duel match against "The Germinator"
Sound Logic - Complete all Puzzle Mode levels

Gold trophies
The Germinator - Collect all stars in Puzzle and Story Mode