Bronze trophies
Bachelor of Escapology - Escaped from the elevator.
Master of Escapology - Escaped from eight rooms.
Escapey - Escaped on Hard difficulty.
Classified - Found a secret.
An Eidetic Experience - Found a file.
Every Ending Begins Somewhere - Saw any of the endings.
That Wasn't Supposed to Happen - Saw any of the bad endings.
To Each According to His Needle - Opened the first lock.
I Can't Believe It's Not Murder! - Opened the second lock.
Gotta Hand It To You - Opened the third lock.
If I Told You You Had A Nice Antibody... - Opened the fourth lock.
He Was Convicted of a String of Numbers - Opened the fifth lock.
No Lying Down On the Job - Opened the sixth lock.
Who Set Up Us The Bomb, Part 1 - Opened the seventh lock.
Why'd You Do That, You Dumas! - Opened the eighth lock.
Who Set Up Us The Bomb, Part A - Opened the ninth lock.
Some Days You Just Can't Get Rid of a Bomb - Opened the tenth lock.

Silver trophies
Doctor of Escapology - Escaped from sixteen rooms.
Tears in the Rain - Saw Luna's ending.
Through the Looking Glass - Saw K's ending.
Behind Blue Eyes - Saw Dio's ending.
In Root Beer Veritas - Saw Tenmyouji's ending.
An Equal and Opposite Reaction - Saw Quark's ending.
Secret Agent Woman - Saw Clover's ending.
Best Served Cold - Saw Alice's ending.
Arms Race - Saw Sigma's ending.
Time After Time - Saw Phi's ending.

Gold trophies
A Consumate Collection - Found ALL the files!
Escapest - Escaped everything on Hard difficulty.
Redacted - Found ALL the secrets!
Fire and Ice - Saw the end. Or maybe the beginning?
A Certain Point of View - Caught a glimpse of another time.

Platinum trophy
Virtue's Last Reward - Earn all Bronze, Silver, and Gold trophies.