To unlock infinite ammunition, beat each mission with an "S" rank on Hard difficulty.

Unlock the following scenarios by performing the corresponding tasks:

SCENARIO - HOW TO UNLOCK
Beginnings (I) - Defeat "Train Derailment 3"
Beginnings (II) - Defeat "Beginnings (I)" with at least an A rank
Dark Legacy (I) - Defeat "Fall of Umbrella 3"
Dark Legacy (II) - Defeat "Death's Door" and "Nightmare (II)"
Death's Door - Defeat "Raccoon's Destruction 3" with at least an A rank
Fourth Survivor - Defeat "Dark Legacy (II)"
Nightmare (I) - Defeat "Mansion Incident 1"
Nightmare (II) - Defeat "Nightmare (I)" with at least an A rank
Rebirth (I) - Defeat "Mansion Incident 3"
Rebirth (II) - Defeat "Rebirth (I)"
The 4th Survivor - Defeat "Dark Legacy (II)"

To unlock co-op play for all missions including sub-missions, beat "TheFourth Survivor" sub-mission. Choose "Begin with two players" on thecharacter select menu (it is a graphic that appears to be two guns onthe right side of the screen) to play co-op.

Unlock the following classic items by reaching the specified ranks on the corresponding chapters:

CLASSIC ITEM - HOW TO UNLOCK
Battery - Beat Dark Legacy 2 with an S Rank
Blue/Green Leech Charm - Beat Train Derailment 3 with an A Rank
Blue/Red/Green Chemical - Beat Umbrella's End 2 with an A Rank
Blue/Red/Yellow Gemstone - Beat Rebirth 2 with an A Rank
Book of Wisdom/Future Compass - Beat Raccoon's Destruction 1 with an S Rank
Briefcase - Beat Train Derailment 1 with an S Rank
Chronos Key - Beat Raccoon's Destruction 3 with an S Rank
Clark/Gail X-Ray - Beat Rebirth 1 with an A Rank
Crystal/Obsidian/Amber Ball - Beat Raccoon's Destruction 3 with an A Rank
Cylinder Shaft - Beat Nightmare 1 with an A Rank
Death Mask - Beat Rebirth 2 with an S Rank
Eagle/Serpent/Jaguar Stone - Beat Fourth Survivor with an S Rank
Emblem/Gold Emblem - Beat Nightmare 2 with an S Rank
Film A/B/C/D - Beat Umbrella's End 1 with an S Rank
Fire/Water Key - Beat Beginning 2 with an A Rank
Fuel Canteen - Beat Mansion Incident 3 with an S Rank
G-Virus - Beat Fourth Survivor with an A Rank
Hex CRank - Beat Nightmare 1 with an S Rank
Ink Ribbon - Beat Umbrella's End 3 with an S Rank
Joint N/S Plug - Beat Raccoon's Destruction 2 with an A Rank
King/Knight/Bishop/Rook Plug - Beat Dark Legacy 1 with an A Rank
Last Book, Vol. 1/2 - Beat Nightmare 2 with an A Rank
Lighter Fluid - Beat Raccoon's Destruction 2 with an S Rank
Medium Base - Beat Dark Legacy 1 with an S Rank
Microfilm A/B - Beat Beginning 2 with an S Rank
Mixing Set - Beat Train Derailment 1 with an A Rank
MO Disk - Beat Mansion Incident 3 with an A Rank
Motherboard - Beat Beginning 1 with an A Rank
Picture (Ada and John) - Beat Death's Door with an A Rank
Plastic Bomb/Detonator - Beat Umbrella's End 1 with an A Rank
Relief of Discipline/Obedience/Unity - Beat Train Derailment 2 with an S Rank
S.T.A.R.S. Card (Brad's) - Beat Death's Door with an S Rank
S.T.A.R.S. Card (Jill's) - Beat Raccoon's Destruction 1 with an A Rank
Slide Cartridge - Beat Rebirth 1 with an S Rank
Spade/Diamond/Club/Heart Key - Beat Dark Legacy 2 with an A Rank
Square CRank - Beat Umbrella's End 2 with an S Rank
Statue of Good/Evil - Beat Train Derailment 2 with an A Rank
Sterilizing Agent - Beat Train Derailment 3 with an S Rank
Sun/Star/Moon Crest - Beat Mansion Incident 2 with an A Rank
V-Jolt - Beat Mansion Incident 2 with an S Rank
Vaccine - Beat Umbrella's End 3 with an A Rank
Valve Handle - Beat Beginning 1 with an S Rank

The Handcannon is located in the "Fourth Survivor" scenario, in ahidden room in the police station's lobby near the front door. Shootthe doors open and pick up the Handcannon on the desk.

To unlock the Special Stage mini-game, successfully complete all scenarios, including the bonus sub-scenarios.

On the loading screen, you can shoot the Umbrella logo and bounce around as you shoot it.

Shoot their head. You can also wait until just before they bite you and shoot their mouth, killing them with one shot almost every time.

Shoot their head while they‘re on the floor. When they are crawling on the roof, shoot them with the shotgun or an automatic weapon since it’s difficult to kill them while they are there.

The worm moves left and right at the beginning to confuse you on which side he will be attacking from. His weak point is in his mouth. Use the assault shotgun, Magnum, rocket launcher, or MRL. Dodge his underground attack. When he comes back up, you’ll look up into the sky. Shoot the rocks coming down and repeat the process. He will jump into the air a few times also. Shoot his mouth to send him flying to the side. Once his health gets down to half, shoot four MRL rockets into is mouth. If he lives, finish him with the assault shotgun. Note: The bus that he throws when tossing cars will take out half of your health. Make sure to shoot the bus and other vehicles to make them explode.

Shoot them while they are jumping in the air or at you for a one-shot kill.

Sometimes they can be put down with one shot if you wait until they open their mouths and shoot.

Always shoot their head, no matter what weapon.

Nemesis has no weak point so simply throw everything you have at him. Make sure you have an assault shotgun (level 4), Magnum (level 4), and MRL (level 4). Use the Magnum first. After you shoot him enough times, he will jump onto the rooftop and run around to a certain spot. He’ll then shoot his tentacles down the wall and pop up directly in front of you to attack. This can’t be dodged. He will then jump up and attempt to crush you. Dodge this, and repeat the process. Use the MRL when you run out of ammo for the Magnum and assault shotgun. Shoot all eight rockets at him and if he survives, finish him off with the handgun. Note: He can grab you and hold you in the air. You’ll die if you don’t shoot him to escape.

-Play Wesker's Mansion Mission (Rebirth) and play the first scenario repeatedly. Once you find all three files, all you need to worry about is critical hits and time. It‘s a short mission so playing it repeatedly doesn‘t get tedious. Once you get the three files, getting an "S" rank is easy. Get all your critical hits after going up the steps. Once the zombies begin moving, aim your crosshair until the red circle blinks, then fire for an instant critical. Also, be sure to always throw grenades into groups of enemies.

Once you level all weapons to Level 4, you may then level them to Level 5. Reach Level 5 with a weapon for unlimited ammunition.

To get easy points, play "Train Derailment" repeatedly. It is easy to earn an "S" rank on this level and you will get 4 or 5 points for every "S" rank you earn.